About & Methodology
Follow the evidence, not the hype
The Peptide Evidence Registry is an independent educational evidence resource. It exists because the gap between what peptide marketing claims and what the research actually shows is enormous — and that gap deserves to be mapped in plain English.
What the Registry is
The Registry maps scientific evidence, clinical development and regulatory context for peptides, GLP-1 medicines and related emerging compounds. It is designed to help readers distinguish established human evidence from preliminary research, preclinical findings, anecdotes and marketing claims.
It is not a peptide vendor directory, a clinic, a regulator, a medical authority or a marketplace. It does not assess batch purity, certificates of analysis or supplier quality because it does not recommend or rank suppliers in the first place.
How ratings are made
- Every compound is placed on a single 0–5 evidence hierarchy, from anecdote to replicated randomised trials.
- Human efficacy, preclinical evidence and human safety evidence are scored separately, because they genuinely diverge.
- Claims are graded on how they are actually worded in the wild, not on a charitable reinterpretation.
- Where no human data exist, we say so explicitly rather than filling the gap with mechanism.
- Ratings are revised when evidence moves, and material revisions are logged publicly.
How evidence is verified
The Registry uses a layered verification workflow rather than treating any search result, AI summary or database hit as evidence on its own. Discovery tools can help find candidate papers; the underlying paper, trial record, regulator document or official study record is what the editorial judgement rests on.
- Primary papers, ClinicalTrials.gov records, regulator documents and official study records are checked before they are treated as canonical evidence.
- Peer-reviewed reviews and academic discovery services such as Consensus can help locate, cross-check and contextualise literature, but they do not independently set a Registry grade.
- Sponsor announcements are labelled as sponsor-reported and are not silently upgraded to peer-reviewed evidence.
- Human, animal, cell and mechanistic findings remain separate; a plausible mechanism is never used as a substitute for a human outcome.
- Contradictions, missing evidence and unresolved source problems are kept visible rather than averaged away.
- AI can assist retrieval, comparison and contradiction checking, but publication and evidence-grade decisions remain human editorial decisions.
On compound profiles, the Source Transparency panel shows the current reference mix and any sources still awaiting curation. Source counts describe provenance, not scientific quality: one strong trial can matter more than many weak papers.
Review freshness and reviewer attribution
- Every compound profile carries a visible last editorial review date and source-provenance summary.
- Profiles crossing 90 days since editorial review are flagged for maintenance attention. This is an operational cue, not a scientific expiry date and not proof that the information is wrong.
- A fresh review date means the Registry record was reviewed; it does not guarantee that no study, preprint or regulatory update has appeared since that date.
- External specialist review is credited only when a named reviewer has completed a review of that exact profile and the scope of the review can be stated.
- General correspondence, expressions of interest, project advice or academic contacts are never presented as endorsement or review of the Registry.
What this site will never do
- No doses, protocols, cycles or administration guidance.
- No supplier reviews, sourcing links, discount codes or affiliate arrangements with peptide sellers.
- No personalised medical advice, and no assessment of whether something is right for you.
- No paid evidence grades, sponsored claim verdicts or commercial placement disguised as scientific evidence.
- No pretending uncertainty away in either direction — hype and blanket dismissal are both dishonest.
Editorial independence
No peptide supplier, compounding pharmacy, clinic or manufacturer pays for inclusion, evidence ratings, claim verdicts or editorial placement. Commercial availability is not treated as evidence of efficacy, safety, quality or approval.
The Registry is created and edited by Colin Jackson-White, who also builds the separate fitness project My Gym Buddy. That sister project does not set Registry evidence ratings, claim verdicts or regulatory descriptions.
Who writes and reviews it
The Peptide Evidence Registry is created and edited by Colin Jackson-White, who is not a doctor or clinician. The editorial position is deliberately simple: explain what the evidence supports, name what it doesn’t, and never let enthusiasm do the work of data.
The project does not currently claim a formal medical or academic review board. External scientific, clinical and methodological review is a development goal and will be described transparently when it exists, rather than claimed in advance.
Research and Educational Use Disclaimer
This website is provided for research and educational purposes only. It is intended to present factual, evidence-based information about peptides, related compounds, and relevant human, animal, and preclinical studies.
The information on this site is not intended to diagnose, treat, cure, or prevent any disease or medical condition, and it should not be considered a substitute for advice from a qualified healthcare professional. Nothing on this site should be interpreted as medical advice, prescribing guidance, or a recommendation to use any peptide, medicine, supplement, or research compound.
Evidence may include human clinical data, animal studies, in vitro research, and other preclinical findings. Where evidence is limited, emerging, conflicting, sponsor-reported or not directly applicable to humans, this should be stated rather than silently upgraded into certainty.
The purpose of this site is to help users understand the current evidence, known limitations, safety considerations, and regulatory context surrounding peptides and related research.
Educational content only