2026-08-23L2Preclinical
Registry-wide
Editorial update: registry expanded from 42 to 56 curated compounds, adding major approved peptide medicines across oral, nasal, injectable and implant routes, plus a source-completeness layer on every profile.
Follow the evidence, not the hype
Peptides and GLP-1s, without the nonsense.
Plain-English, evidence-led explanations of what is actually proven, what looks promising, what is still experimental and what nobody honestly knows yet. Human trials kept separate from mouse studies, cell dishes and confident strangers on the internet.
Try “BPC-157”, “retatrutide”, or “heals tendons”.
No bro-science. No miracle claims. No pretending mice are tiny humans.
Start somewhere
Seven ways into the evidence, depending on what you came for.
GLP-1s
Semaglutide, tirzepatide, retatrutide and the rest.
Tissue repair
BPC-157, TB-500 and the healing claims.
Mitochondria
MOTS-c, SS-31 and energy metabolism.
Longevity
Telomeres, ageing biology and lifespan claims.
Skin & hair
GHK-Cu and cosmetic evidence.
Cancer context
Theoretical concern vs demonstrated risk.
Research literacy
How to read a study without being fooled.
Featured evidence positions
Six compounds that show how differently the evidence can stack up.
Tirzepatide
A dual GIP and GLP-1 receptor agonist with strong Phase 3 weight and glycaemic data.
L5Practice-changingApproved medicineHigh confidence
SC injection
GLP-1s & incretins
Retatrutide
An investigational GIP/GLP-1/glucagon triple agonist in an advanced Phase 3 metabolic programme.
L4Strong humanInvestigationalHigh confidence
SC injection
GLP-1s & incretins
BPC-157
The internet's favourite healing peptide: a mountain of rodent data and almost no controlled human evidence.
L2PreclinicalExperimental / researchVery low confidence
SC injection· unapprovedNasal· unapprovedOral· unapproved
Evidence is mostly preclinical
Tissue repair
TB-500 / Thymosin beta-4
A genuine biological protein with real research history, and a separate online product that is not quite the same thing.
L2PreclinicalExperimental / researchVery low confidence
OphthalmicTopicalSC injection· unapproved
Evidence is mostly preclinical
Tissue repair
MOTS-c
A mitochondrial-derived peptide with genuinely interesting biology and thin translational data.
L2PreclinicalExperimental / researchVery low confidence
SC injection· unapproved
Evidence is mostly preclinical
MitochondriaLongevity
SS-31 / Elamipretide
A mitochondria-targeting peptide with a narrow accelerated approval and a much broader set of unproven anti-ageing claims.
L3Early humanApproved — narrow indicationLow confidence
SC injection
MitochondriaLongevity
How the evidence grading works
One scale, used everywhere on this site. Levels do not accumulate — a hundred mouse studies never become a human trial.
L5
Level 5 — Practice-changing
Replicated large randomised trials, pivotal Phase 3 programmes, or a major regulatory decision.
L4
Level 4 — Strong human evidence
Solid controlled human trials, though not yet definitive or fully replicated.
L3
Level 3 — Preliminary human signal
Small, short or uncontrolled human studies. Suggestive, not conclusive.
L2
Level 2 — Preclinical
Animal, organoid or tissue studies. Mice are not tiny humans.
L1
Level 1 — Mechanistic
Cell, receptor or computational work explaining how something could work.
L0
Level 0 — Anecdote
Testimonials, forum reports and influencer claims. Interesting, never evidence.
Latest evidence updates
Baseline entries showing how positions get recorded and revised.
2026-08-23L2Preclinical
Registry-wide
Editorial update: major taxonomy expansion from 15 to 42 curated compounds, adding approved peptide medicines and high-interest research compounds.
2026-08-23L1Mechanistic
Semax, DSIP, KPV and related research peptides
Editorial update: profiles created or revised using FDA 2026 Pharmacy Compounding Advisory Committee material.
2026-07-10L2Preclinical
BPC-157
Baseline entry: registry position set to preclinical-only for musculoskeletal healing claims.
Educational information only
This site explains research. It does not give medical advice, personalised protocols or dosing guidance, and it does not point anyone at suppliers. If you are making decisions about your own body, involve a qualified clinician.
Sister project
Science here. Practical training over there.
The Peptide Evidence Registry handles the research, the evidence grading and the education. My Gym Buddy is where the practical fitness and wellbeing tools live — training, habits and day-to-day progress.
The creator
Created by Colin Jackson-White
Colin is the creator and editor of The Peptide Evidence Registry — not a doctor or clinician. The project exists for one reason: peptide and GLP-1 research moves faster than most people can read it, and the gap gets filled by marketing. This registry translates that research into evidence summaries you can actually follow, and says plainly when the honest answer is “nobody knows yet”.