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Comparison Centre

Two compounds, the same questions, no cherry-picking

Marketing compares compounds on whichever measure flatters them. This compares them on the same fields every time — including the awkward ones like how much human safety data exists. Every score here rates the evidence, not the compound: a higher number means stronger or more mature research, not that something is safer or works better.

Sharing keeps the two compounds you picked.

How to read these scores

Every number here rates the evidence, not the compound. They are editorial 0-100 strength ratings, not percentages, and not a rating out of five stars.

  • Human efficacy evidence strength — Higher = more and better-quality human evidence. It does not mean the effect is bigger or that the compound works for you.
  • Preclinical evidence strength — Higher = more animal, tissue or cell research. Preclinical results are a starting point, not proof of a human benefit.
  • Human safety evidence strength — Higher = more mature, better-documented human safety data. It does not mean the compound is safer than one with a lower number. A score of 80 does not mean “80% safe”.
  • Evidence level (L0-L5) — the strongest type of study behind the compound, from anecdote (L0) to large replicated human trials (L5). It is a description of the study evidence, not a quality, safety or recommendation rating.
  • Confidence — how likely we think it is that this rating changes as new research lands. Low confidence means the picture is unsettled, not that the compound is bad.

None of these ratings is medical advice, a safety guarantee, or a recommendation to use anything. How we grade evidence.

Selank

A synthetic heptapeptide related to tuftsin, marketed online for anxiety despite no regulatory approval and almost no independent human evidence.

L1Theory onlyResearch / unapproved supply
Full profile

Semax

A synthetic heptapeptide derived from an ACTH fragment, registered as nasal drops in Russia and heavily marketed elsewhere as a nootropic.

L2Animal / lab studiesResearch / unapproved supply
Full profile

How far human research has progressed

Selank

No established Western clinical programme

Semax

Registered in one national market; limited Western-quality controlled evidence

Claim-specific benefit evidence

A human exposure study or trial registration does not establish that the claimed benefit occurs.

Selank

Not separately assessed; see the full profile.

Semax

Not separately assessed; see the full profile.

Human research context

Selank

No established Western clinical programme

Semax

Registered in one national market; limited Western-quality controlled evidence

Human efficacy evidence strength

Higher = more and better-quality human evidence. It does not mean the effect is bigger or that the compound works for you.

Selank

Strength of the human efficacy evidence8 of 100 evidence strength

Semax

Strength of the human efficacy evidence18 of 100 evidence strength

Preclinical (animal / lab) evidence strength

Higher = more animal, tissue or cell research. Preclinical results are a starting point, not proof of a human benefit.

Selank

Strength of the animal and lab evidence40 of 100 evidence strength

Semax

Strength of the animal and lab evidence50 of 100 evidence strength

Human safety evidence strength

Higher = more mature, better-documented human safety data. It does not mean the compound is safer than one with a lower number.

Selank

Strength of the human safety evidence10 of 100 evidence strength

Semax

Strength of the human safety evidence12 of 100 evidence strength

Regulatory status (legal position, not proof it works)

Selank

Check jurisdiction-specific details in the profile.

Not approved by the FDA or other major Western regulators. FDA compounding safety material states that compounded Selank may pose immunogenicity and impurity risks and that the FDA lacks important human safety information for it.

Semax

Check jurisdiction-specific details in the profile.

Not approved by the FDA or other major Western regulators. FDA material notes Semax is registered in Russia as nasal drops, while intranasal and injectable products marketed in the US are not FDA-approved. FDA has identified it as a bulk substance presenting significant safety risks for compounding — a compounding safety classification, not an 'FDA ban' — and it was covered by FDA's Pharmacy Compounding Advisory Committee meeting on 23-24 July 2026.

Common claims

Selank

  • · Reduces anxiety without sedation
  • · Improves cognition and stress resilience

Semax

  • · Improves memory, focus and mental performance
  • · Speeds recovery after stroke
  • · Helps anxiety and migraine

How settled our evidence rating is

Selank

Very low confidence in ratingL1Theory only

Semax

Very low confidence in ratingL2Animal / lab studies

Cancer-related questions raised by the biology

These are theoretical or monitored questions raised by how a compound works. They are not evidence that it causes cancer.

Selank

No established human cancer signal; systematically unstudied.

Semax

No established human cancer signal and no systematic data either way. The honest position is unstudied.

What this adds up to, in plain English

Selank

This sits in theory and anecdote. Popular claims about it should be treated with very low confidence.

Semax

The interesting work is in animals and lab studies. Treating it as an established human treatment is not supported by evidence.

A comparison is not a recommendation

Neither column here is an endorsement, and the compound with the higher numbers is not the “better” or “safer” one — it is simply the one with more or better-quality research behind it. Two compounds can both be poorly evidenced, and better-evidenced says nothing about whether either is a sensible idea for a specific person. That is a conversation for a qualified clinician.